It goes without saying that COVID-19 is on the minds of nearly every American. The societal and economic disruption is almost without precedent. As government officials and clinicians wrestle with issues of how to protect the public, there seem to be more questions than answers. The mental health effects of COVID-19 are as important to address as are the physical health effects. Social isolation, school closures, lack of structure, financial difficulties, and unemployment are among the many stressors related to COVID-19 that have significant impacts on mental well-being.